Artemisinin and Nitric Oxide: Mechanisms and Implications in by Qing-Ping Zeng

By Qing-Ping Zeng

This e-book discusses either the necessary and damaging features of NO in biology and medication, and in addition introduces the rising discovery of artemisinin in antitumor, antibacterial an infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) used to be voted “Molecule of the yr” by means of technology journal, and the invention of its physiological roles has ended in Nobel Prize-winning paintings in neuroscience, body structure and immunology. The booklet explains why we should always continue a steady-state NO point that's derived from neuronal or epithelial NO synthase, and stay away from the super excessive NO point caused by inducible NO synthase. The publication deals a precious source for clinical chemists, clinicians, biologists and all these drawn to future health and disease.

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1993). Later, ART’s cytotoxicity was shown to be endoperoxide-­dependent (Beekman et al. 1998). -P. 1007/978-3-662-47688-8_3 29 30 3 ART for Antitumor proposed (Kwok and Richardson 2002). Tumor cells in exposure to ART were found to exhibit a correlation of mitigated proliferation with repressed ­angiogenesis (Krishna et al. 2008). Recent evidence suggests that ART may share a common feature with the heme-interacting compound coralyne because both exert the cytotoxicity in a heme-dependent manner (Zhang and Gerhard 2009).

FEBS Lett 345:50-54 Corker H, Poole RK (2003) Nitric oxide formation by Escherichia coli: dependence on nitrite reductase, the nitric oxide-sensing regulator Fnr, and flavohemoglobin Hmp. J Biol Chem 278:31584–31592 Corpas FJ, Barroso JB, Del Rio LA (2004) Enzymatic sources of nitric oxide in plant cells— beyond one protein–one function. New Phytol 162:246–247 Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA (2008) Relationship between antimalarial activity and heme alkylation.

2008). The digestive vacuole is already re-established by a mid-ring stage of the parasite’s blood cycle, a stage sensitive to ART derivatives but not to other antimalarial drugs (Abu Bakar et al. 2010). A study to investigate the action mode of ART using a yeast model has demonstrated that ART targets mitochondria, in which electron transport chains can activate ART, generate ROS, and depolarize mitochondrial membranes (Li et al. 2005). Subsequent studies have confirmed that ART can attack the mitochondria of parasites but not mammalian cells.

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