Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Background Lesions in Laboratory Animals may be a useful relief to pathologists wanting to acknowledge historical past and incidental lesions whereas interpreting slides taken from laboratory animals in acute and protracted toxicity reviews, or whereas reading unique species in a diagnostic laboratory. It offers transparent descriptions and illustrations of nearly all of heritage lesions more likely to be encountered. some of the lesions coated are strange and will be fallacious for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all the laboratory animal species coated and who've released generally in those areas.

  • over six hundred high-definition, premiere colour images of historical past lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive platforms of all laboratory animals written via Dr Dianne Creasy, an international specialist on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts which may be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, fairly in rats in mice that are used for carcinogenicity studies

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Additional resources for Background Lesions in Laboratory Animals. A Color Atlas

Example text

1981. The presence of proximal tubule like cells in the kidney parietal epithelium in response to unilateral nephrectomy. Anat. Rec. 200, 61–65. , 1976. Nucleus circularis: is it an osmoreceptor in the brain? Brain research bulletin 1, 123–131. , 1962. The development of gingival sebaceous-like glands and cysts in rats of the Holtzman strain. Oral Surg. Oral Med. Oral Pathol. 15, 351–354. , 2007. Pulmonary neuroendocrine cell hyperplasia: identification, diagnostic criteria and incidence in untreated ageing rats of different strains.

Crit. Rev. Toxicol. 12, 121–147. , 2010. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol. Pathol. 38, 5S–81S. , 1993. Spontaneous globoid mineralization in the cerebellum of rats. J. Comp. Pathol. 109, 447–451. , 1990. Fordyce’s granules of the incisor and molar gingiva in F344 rats. Vet. Pathol. 27, 432–438. Beagle dog 37 CHAPTER 3 Cheryl Scudamore Beagle dog Introduction The majority of dogs used in toxicity studies are young beagles (generally less than one year old at the start of study), and therefore a limited range of background findings is recognized compared to the ageing population of dogs generally seen in veterinary pathology diagnostic facilities.

200. 71 Cholangiofibrosis in the rat liver. ×100. 73 Herniated liver lobe with fibrosis and inflammation in the pedicle. ×100. Mitotic figures and multinucleated hepatocytes are observed as a background finding in small numbers of rat livers. Multinucleate hepatocytes (Fig. 74) occur spontaneously in older rats (Burek 1978). If these lesions are noted in increased numbers, then the phenomenon may be related to treatment. Apoptosis of hepatocytes is observed at very low levels in rat livers (Detilleux et al 1995).

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