By Stanley Letovsky (auth.), Stanley Letovsky (eds.)
Bioinformatics brings computational easy methods to the research and processing of genomic facts. Bioinformatics: Databases and Systems makes a speciality of the problems of procedure construction and knowledge curation that dominate the daily issues of bioinformatics practitioners. integrated are chapters through a lot of brand new best bioinformatics practitioners, describing lots of the present paradigms of approach construction and curation, together with either their strengths and weaknesses. organic subject matters lined comprise series databases, metabolic pathways, phenotypes, style collections, gene expression atlases and neuroinformatics. Species variety from micro organism to mammals to crops. software program structures and applied sciences lined comprise OPM, CORBA, SRS, KLEISLI, ACEDB, Web-based integration and laboratory workflow.
Bioinformatics: Databases and Systems offers a precious advent for rookies to the sector, and an invaluable reference for veterans.
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Extra info for Bioinformatics: Databases and Systems
Genetic Nomenclature Guide. Maize. , and Selkov, E.. Representation of Function: The Next Step. Gene-COMBIS (on-line): 31 January 1997; Gene 191, no. , and Yunus, I. The Methabolic Pathway Collection from EMP: The Enzymes and Metabolic Pathways Database. Nucleic Acids Research, 24, no. 1 (database issue), 1996, pp. 26-29. 4 ECOCYC: THE RESOURCE AND THE LESSONS LEARNED Peter D. Karp* and Monica Riley** 65, ,QWHUQDWLRQDO 5DYHQVZRRG $YHQXH 0HQOR 3DUN &$ 86$ SNDUS#DLVUL&RP 0DULQH %LRORJLFDO /DERUDWRU\ :RRGV +ROH 0$ PULOH\#PEOHGX Introduction The EcoCyc DB has several organizing principles.
Com / ecocyc / for more information. 59 Figure 5: The software architecture of EcoCyc. The components include a graphmanagement system called Grasper-CL , an API for FRSs called the Generic Frame Protocol, and the CWEST tool for retrofitting CLlM applications to run through the WWW . Lessons Learned from the EcoCyc Project This section presents the bioinformatics contributions of the EcoCyc project and the lessons learned in the course of the project, and notes properties of EcoCyc that distinguish it from some other biological DBs.
L. Yeager, M. Comparative evolutionary rates of introns and exons in murine rodents, J. Mol. 125-130. 27. , D'Onofrio, G. Bernardi, G. Nonrandom frequency patterns of synonymous substitutions in homologous mammalian genes, J. Mol. 280-292. 28. , Hughes, S. Mouchiroud, D. The major compositional transitions in the vertebrate genome, J. Mol. S44-S5 1. 29. , Gautier, C. Mouchiroud, D. Evolution of isochores in rodents, Mol. Biol. 823-828. 30. , Mouchiroud, D. Gautier, C. Statistical analysis of vertebrate sequences reveals that long genes are scarce in GC-rich isochores, J.