By Edward C. Feldman DVM DACVIM, Richard W. Nelson DVM, Visit Amazon's Claudia Reusch Page, search results, Learn about Author Central, Claudia Reusch, , J. Catharine Scott-Moncrieff
No different identify deals such commitment to the intensity, adventure, and concentration of endocrinology as Canine and pussycat Endocrinology, 4th Edition. accomplished insurance contains almost each universal and unusual situation in endocrinology, plus the main up to date details on meals, geriatric care, pathophysiology, checking out systems, and within your means and expedient diagnostic protocols. With its logical, step by step assistance for selection making, prognosis, and prescribing, you can be well-equipped to deal with the extensive spectrum of endocrine and metabolic problems in canine and cats.
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Extra info for Canine and Feline Endocrinology, 4e
Solutes that are less permeable across cell membranes by virtue of molecular size, electrical charge, or active membrane pumps create an effective osmotic force. Intracellular solutes of this kind include potassium, phosphate, glucose and protein. Sodium and its anions serve the same purpose in the extracellular fluid (ECF). Increased concentrations of such solutes in the ECF produce hyperosmolality and hypertonicity. The osmotic gradient that is formed results in movement of intracellular fluid (ICF) into the extracellular space.
MRI has been used to identify the presence of vasopressin in the posterior pituitary in humans. On T1-weighted images, MRI produces a bright spot in the sella caused by stored hormone in the neurosecretory granules in the posterior pituitary (Moses et al, 1992; Kurokawa et al, 1998). , 2003). The bright spot decreases with a prolonged stimulus for vasopressin secretion and has been variably reported in other polyuric disorders (Fujisawa et al, 2004). A bright spot in the region of the posterior pituitary has also been identified in dogs and presumably represents vasopressin stored in neurosecretory | CHAPTER 1 Water Metabolism and Diabetes Insipidus 29 BOX 1-5 T herapies Available for Polydipsic/Polyuric Dogs with Central Diabetes Insipidus, Nephrogenic Diabetes Insipidus, or Primary (Psychogenic) Polydipsia FIGURE 1-29 Magnetic resonance imaging (MRI) T1-weighted transverse image of the pituitary gland in a healthy adult dog illustrating the hyperintense “bright spot” (arrow) in the sella.
This reduction is associated with a proportional rise in urine osmolality, correction of dehydration, and a reduction in fluid consumption similar to that observed with small doses of vasopressin (Robertson, 1981). The exact mechanism of the potentiating effect of chlorpropamide on the action of AVP in the kidney is not known. Chlorpropamide may enhance AVP stimulation of renal medullary cAMP by augmenting adenylate cyclase sensitivity to AVP or by inhibiting phosphodiesterase (Reeves et al, 1998).