By Dick Hoekstra (Eds.)
Hard and provocative overviews are provided in quantity forty of Current themes in Membranes . subject matters on mobile lipids fluctuate from easy subject matters reminiscent of biosynthesis and membrane distribution to the position of lipids in intracellular signaling and membrane circulation. This unmarried quantity additionally highlights the jobs of lipids in eukaryotic cells and discusses association of lipids in microdomains.
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Additional info for Cell Lipids
Falciparum-infected human erythrocytes with bee venom phospholipase A,, sphingomyelinase C, and TNBS, although changes in PS distribution were observed only with TNBS. , 1987). The observations just discussed contrast with those obtained by van der Schaft et af. (1987b) and Beaumelle et al. (1988), who showed a normal asymmetry for SM and PS in P. knowlesi-infected monkey erythrocytes using phospholipases, fluorescamine, and merocyanine 540. , 1987b), the suitability of such probes under these conditions was doubted.
Interestingly, the very first appearance of PS in the exofacial leaflet of these cells coincided markedly with a drop in cellular ATP to 10% of the original level. , 1988,1989b). The observations just discussed suggest that, in diamidetreated (fresh) erythrocytes, the aminophospholipid translocase is still in operation, a suggestion that appears to be in conflict with the reported inhibitory effect that this treatment supposedly exerts on the flippase 18 Ben Roelofsen and Jos A. F. Op den Kamp (Daleke and Huestis, 1985,1989; Connor and Schroit, 1988,1990,1991).
Section IV) is present and active for both PS and PE, its activity results in an asymmetric distribution of PS, but not of PE. This remarkable situation might be a consequence of the fact that, in contrast to the mature red cell, this precursor cell still lacks a completely assembled membrane skeletal network and, therefore, its contribution to stabilizingthe proper asymmetric phospholipid distribution that is known to exist in the mature red cell. IV. MAINTENANCE OF PHOSPHOLIPID ASYMMETRY A. ATP-Dependent Arninophospholipid Translocation The presence, in the erythrocyte membrane, of a system that mediates an active transport of both aminophospholipids from the outer to the inner 1.