Endometrial Stem Cells and Its Potential Applications by Indumathi Somasundaram

By Indumathi Somasundaram

Stem cells have ushered in frequent curiosity and intriguing chances for mobile established remedies. regardless of a number of projects and meticulous untiring efforts, translating this bench aspect study into bedside perform and remedies continues to be a problem. a greater realizing of increasing examine in particular components of stem cells is important in constructing regenerative scientific therapeutics. With their specific attributes, reviews on stem cells of endometrium and its healing purposes at either in-vitro and at pre-clinical settings in well-being and ailment states are gaining consensus in recent times. This SpringerBrief offers a radical yet succinct presentation of strong information regarding the importance of stem cells from the endometrium, the internal lining of the uterus. It provides an figuring out of stem cells derived from human endometrium and consider how cells from those assets are getting used to investigate and therapeutics for numerous medical difficulties and ailments. furthermore, short additionally discusses the threats and demanding situations dealing with endometrium. total, it illuminates the desire that, the stem cells of endometrium will be an efficient resource of therapeutics for a large number of disorders.

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Isolated and cultured the cells in Chang’s complete medium, and the cultured population were used for CD117+ sorting using magnetic activated cell sorter (MACS). The remaining cells were cryopreserved using precooled DMSO, 30 % PBS, and 10 % HSA. Many hysterectomies are performed yearly in the country, and thus endometrium is supposed to be a potential source of stem cells. Studies have indicated that these stem cells reside in the superficial layers accessible by endometrial biopsy. As routinely performed for gynecologic purposes and does not impair endometrial function, endometrial stem cells become ideal source.

A major advantage of being able to identify the cell surface markers of epithelial and stromal population of the endometrium is that their features can be characterized in non-cultured cells and their utility in cell-based therapies for regenerative medicine could be evaluated in preclinical disease models. Furthermore, a detailed study of endometrial stem cell markers is necessary as pathology of several endometrial disorders such as abnormal uterine bleeding leading to endometrial hyperplasia, infertility, pregnancy complications, miscarriage, endometriosis, and cancer is associated with these endometrial progenitor/stem cells.

2011;3:4–10. Borlongan CV, Kaneko Y, Maki M, Yu SJ, Ali M, Allickson JG, Sanberg CD, Kuzmin-Nichols N, Sanberg PR. Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke. Stem Cells Dev. 2010;19:439–52. Cui CH, Uyama T, Miyado K, Terai M, Kyo S, Kiyono T, Umezawa A. Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation.

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