Epigenetics - A Different Way of Looking at Genetics by Walter Doerfler, Petra Böhm

By Walter Doerfler, Petra Böhm

This e-book offers epigenetics study as a brand new manner of genetics. issues diversity from simple epigenetics mechanisms to improvement of cells and organisms and the organic foundation of ailments. furthermore the ebook makes a speciality of immunology and the position of viruses in epigenetics. The final a part of the ebook highlights proteins and peptides as epigenetic modulators.

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During the last years, several of the responsible histone-modifying enzymes have been identified, and this has allowed functional studies to be performed (Kelsey and Feil 2013). Particularly, chromatin associated with the DNA-methylated alleles of ICRs is consistently enriched in histone H3 lysine 64 trimethylation (H3K64me3), H3 lysine 9 trimethylation (H3K9me3), H4 lysine 20 trimethylation (H4K20me3), and H4 arginine 3 symmetrical dimethylation (H4R3me2s) and is bound by the heterochromatin protein 1 gamma (HP1γ) as well (Delaval et al.

Several other proteins are involved in the process as well. 1). One of these is ZFP57 (Li et al. 2008), a KRAB domain zinc finger protein which recruits KAP1 (also called TRIM28 or TIF1B) to the chromatin. The KAP1 “platform protein” in turn, mediates recruitment of histone-modifying enzymes, including the H3 lysine 9-specific ESET/SETDB1, which regulates H3K9me3 at ICRs (Hirasawa and Feil 2008). Significantly, ZFP57 binds to methylated DNA sequences only and recognizes a specific sequence motif (“TGCCGC”) found at most ICRs and at some other, differentially methylated regions (DMRs) as well (Quenneville et al.

Annu Rev Microbiol 62:193–210 Weening EH, Barker JD, Laarakker MC, Humphries AD, Tsolis RM, Baumler AJ (2005) The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in mice. Infect Immun 73(6):3358–66 Wion D, Casadesu´s J (2006) N6-methyl-adenine: an epigenetic signal for DNA-protein interactions. Nat Rev Microbiol 4:183–92 Wood RL, Pospischil A, Rose R (1989) Distribution of persistent Salmonella typhimurium infection in internal organs of swine.

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