From Molecules to Networks. Introduction to Cellular and by John H. Byrne, Ruth Heidelberger, M. Neal Waxham

By John H. Byrne, Ruth Heidelberger, M. Neal Waxham

An figuring out of the fearful process at almost any point of research calls for an figuring out of its easy development block, the neuron. The 3rd version of From Molecules to Networks offers the forged beginning of the morphological, biochemical, and biophysical houses of nerve cells. based on earlier variants, the original content material specialize in mobile and molecular neurobiology and comparable computational neuroscience is maintained and stronger.

All chapters were completely revised for this 3rd variation to mirror the numerous advances of the earlier 5 years. the hot variation expands at the community facets of mobile neurobiology by way of including new insurance of particular learn tools (e.g., patch-clamp electrophysiology, together with functions for ion channel functionality and transmitter free up; ligand binding; structural tools reminiscent of x-ray crystallography).

Written and edited via prime specialists within the box, the 3rd version thoroughly and comprehensively updates all chapters of this distinct textbook and insures that every one references to fundamental study symbolize the most recent results.

  • The first remedy of mobile and molecular neuroscience that incorporates an creation to mathematical modeling and simulation approaches
  • 80% up to date and new content
  • New bankruptcy on "Biophysics of Voltage-Gated Ion Channels"
  • New bankruptcy on "Synaptic Plasticity"
  • Includes a bankruptcy at the Neurobiology of Disease
  • Highly referenced, accomplished and quantitative
  • Full colour, expert photographs throughout
  • All snap shots come in digital model for instructing purposes

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Additional resources for From Molecules to Networks. Introduction to Cellular and Molecular Neuroscience

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1896). The psychical nerve cell in health and disease. Bull. Johns Hopkins Hosp. 7, 162–164. , Wouterlood, F. , and Van den Pol, A. N. ) (1990). “Handbook of Chemical Neuroanatomy”, Vol. 8. Elsevier, Amsterdam. , and Braak, E. (1982). Neuronal types in the striatum of man. Cell Tissue Res. 227, 319–342. Bradbury, M. W. B. (1979). “The Concept of a Blood–Brain Barrier”, pp. 381–407. Wiley, Chichester. Brightman, M. , and Reese, T. S. (1969). Junctions between intimately apposed cell membranes in the vertebrate brain.

42, 931–942. , and Norton, W. T. (1980). Myelin. Sci. Am. 242, 88–118. Mountcastle, V. B. (1978). An organizing principle for cerebral function: The unit module and the distributed system. In “The Mindful Brain: Cortical Organization and the Group-Selective Theory of Higher Brain Function” (V. B. Mountcastle and G. ), pp. 7–50. MIT Press, Cambridge, MA. -A. (1994). Neurological mouse mutants and the genes of myelin. J. Neurosci. Res. 38, 607–612. , Bloom, F. , and Milner, R. J. (1987). Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM20 protein of central nervous system myelin.

In contrast to the axon, Nissl substance extends into dendrites, and certain proteins are synthesized predominantly in dendrites. There is evidence for the selective placement of some mRNAs in dendrites as well (Steward, 1995). For example, whereas RER and polysomes extend well into the dendrites, the mRNAs that are transported and translated in dendrites are a subset of the total neuronal mRNA, deficient in some mRNA species (such as neurofilament mRNAs) and enriched in mRNAs with dendritic functions (such as microtubule-associated protein mRNAs, microtubule-associated protein 2).

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