Handbook of Psychopharmacology: Volume 13 Biology of Mood by Arthur J. Prange Jr., Charles B. Nemeroff (auth.), Leslie L.

By Arthur J. Prange Jr., Charles B. Nemeroff (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)

Underlying the layout of the instruction manual of Psychopharmacology is a prejudice that the research of drug impacts at the brain has complicated to a level the place simple study and scientific program really mesh. those later volumes of the instruction manual are based in response to this belief. In convinced volumes, teams of gear are handled as periods with chapters starting from simple chemistry to medical program. different volumes are assembled round subject parts corresponding to anxiousness or affective problems. therefore, along with chapters on person drug sessions, we've integrated essays addressing wide components corresponding to "The Limbic-Hypothalamic-Pituitary-Adrenal method and Human Be­ havior" and "Peptides and the primary anxious approach. " Surveying those various contributions, one comes away with a sentiment that, faraway from being an "applied" technological know-how borrowing from basic mind chemistry and body structure, psychopharmacology has as a substitute supplied easy researchers with the instruments and conceptual methods which now are advancing neurobiology to a primary function in smooth biology. in particular pleasurable is the feel that, whereas contributing to an knowing of ways the mind capabilities, psychopharmacology is a self-discipline whose culmination provide actual support to the mentally ailing with grants of escalating merits sooner or later. L. L. 1. S. D. 1. S. H. S. vii CONTENTS bankruptcy 1 Peptides and the important anxious procedure ARTHUR]. PRANGE, ]R. , CHARLES B. NEMEROFF, MORRIS A. LIPTON, GEORGE R. BREESE, and IAN C. WILSON 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Hypothalamic freeing Hormones: Animal reviews. . . . . 2 2. 1. Thyrotropin-Releasing Hormone (TRH, Thyroliberin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Since L-dopa is useful in Parkinson's disease, PLG was examined for possible L-dopa-potentiating effects. Plotnikoff et al. p. , 1974, 1975). Plotnikoff et al. (1974c) later showed that PLG could be given orally and that mice could be HPX with no decrement in the phenomenon. A variety of organ ablations similarly had no effect. Repeated PLG administration did not reveal either tolerance or cumulative effects. In intact mice repeated treatment had no effect on whole-brain level of DA, NE, or 5-HT.

Nicoll (1974), the induction of parental behavior has been reported to occur after PRL administration in pheasants, turkeys, chickens, and ring doves. These results are, however, controversial; progesterone may be the prime inducer of incubation behavior. What is clear is that in several avian species, pituitary PRL levels are highest during egg incubation. In fact, it has been shown that in species in which the male incubates the eggs and broods the hatchlings, his pituitary content of PRL rises 600%, whereas that of the female only doubles.

Zimmerman and Krivoy (1973) have reported that the injection of 20 ILg J3-MSH or ACTH l - 2Jkg antagonized the depressant action of morphine on monosynaptic and polysynaptic reflexes in spinal cats. Neither peptide altered the cardiovascular response to morphine. This dissociation of morphine action by these two peptides suggests that J3-MSH and ACTH l - 24 may selectively antagonize the neural depressant effects of morphine. In vitro studies on isolated frog spinal cord also indicated that the antagonism between ACTH l - 24 and morphine is due to direct actions on the nervous system (Zimmerman and Krivoy, 1973).

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