Health effects of polyunsaturated fatty acids in seafoods by Artemis P Simopoulos; Robert R Kifer; Roy E Martin; National

By Artemis P Simopoulos; Robert R Kifer; Roy E Martin; National Institutes of Health (U.S.). Nutrition Coordinating Committee.; National Fisheries Institute

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6 = ω-6. A c c u m u l a t i o n ( a n d p h y s i o l o g i c a l effect) s e l d o m o c c u r s u n d e r n o r m a l c o n d i t i o n s s i n c e t h e total c a p a c i t y o f a t i s s u e to f o r m e i c o s a n o i d s is s e l d o m fully e x p r e s s e d * , a n d in n o r m a l t i s s u e s it s e e m s to b e u n d e r t h e c o n t i n u a l c o n s t r a i n t s o f a l i m i t e d s u p p l y o f e i t h e r t h e s u b s t r a t e a r a c h i d o n i c acid or the hydroperoxide activators (7).

Lancet /66. 6. Ahrens EH, Insull W, Hirsch J, et al. (1959). The effect on human serum lipids of a dietary fat, highly unsaturated, but poor in essential fatty acids. Lancet i:115. 7. Bang HO, Dyerberg J. (1972). Plasma lipids and lipoproteins in Greenlandic West Coast Eskimos. Acta Med Scand 292:85. 8. Dyerberg J , Bang HO, Hjorne N. (1975). Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 28:958. 9. Dyerberg J, Bang HO, Stofferson E, Moncada S, Vane JR. (1978).

T h e r e w a s g e n e r a l a g r e e m e n t t h a t t h e availability o f a v a r i e t y o f purified o m e g a — 3 a n d o m e g a — 6 p o l y u n s a t u r a t e s , in sufficient q u a n t i t i e s for f e e d i n g s t u d i e s a n d i n c l u d i n g s e v e r a l d e u t e r a t e d s t a n d a r d s , w o u l d g r e a t l y e x p e d i t e p r o g r e s s in this field. RESPONSES OF FEDERAL AGENCIES TO THE RECOMMENDATIONS In r e s p o n s e to t h e c o n c l u s i o n s a n d r e c o m m e n d a t i o n s p r e s e n t e d at t h e conference, the National Institutes of Health (NIH) and the Alcohol, Drug Abuse, and Mental Health Administration ( A D A M H A ) issued a joint prog r a m a n n o u n c e m e n t entitled " B i o l o g i c a l M e c h a n i s m s O f O m e g a - 3 F a t t y A c i d s In H e a l t h A n d D i s e a s e S t a t e s .

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