How to Overcome the Antibiotic Crisis : Facts, Challenges, by Marc Stadler, Petra Dersch

By Marc Stadler, Petra Dersch

This quantity specializes in antibiotics examine, a box of topical importance for human wellbeing and fitness end result of the being concerned raise of nosocomial infections as a result of multi-resistant micro organism. It covers numerous easy points, akin to the evolution of antibiotic resistance and the effect of antibiotics at the intestine microbiota, and addresses the hunt for novel pathogenicity blockers in addition to historic features of antibiotics. additional themes comprise utilized points, comparable to drug discovery in accordance with biodiversity and genome mining, optimization of lead buildings by means of medicinal chemistry, overall synthesis and drug supply applied sciences. in addition, the advance of vaccines as a legitimate substitute healing strategy is printed, whereas the significance of epidemiological reports on vital bacterial pathogens, the issues coming up from the over the top use of antibiotics in animal breeding, and the improvement of cutting edge applied sciences for diagnosing the “bad insects” are mentioned intimately. hence, the booklet will entice researchers and clinicians alike.

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Extra info for How to Overcome the Antibiotic Crisis : Facts, Challenges, Technologies and Future Perspectives

Example text

The first MRSA was reported already in 1961 (Jevons 1961), which was within a year after the introduction into clinical use of methicillin—a penicillinase-stable beta-lactam antibiotic. Since then, MRSA have emerged multiple times through acquisition of variants of the transferable genetic element SCCmec, which renders staphylococci resistant to all beta-lactams by encoding a peptidoglycan transpeptidase enzyme with low affinity for beta-lactam antibiotics (Robinson and Enright 2004; Nübel et al.

Traits considered in this regard have been virulence (DeLeo Emergence and Spread of Antimicrobial Resistance … 39 and Chambers 2009), tolerance to desiccation and other stresses (Knight et al. 2012; Baldan et al. 2015), resistance to antiseptics (Cooper et al. 2012), or growth rate (Knight et al. 2012), among other factors. However, comparative Genomics has as yet revealed little convergence of genomic traits among major MRSA strains aside from antibiotic resistance. Therefore, it remains unclear to what extent those widely disseminated strains have been favored by any selective edge.

And Pseudomonas aeruginosa in 2010. Curr Opin Microbiol 10(5):436–440 Otto M (2012) MRSA virulence and spread. S. hospitals, 1975–1991. Infect Control Hosp Epidemiol 13(10):582–586 Parida SK, Axelsson-Robertson R, Rao MV, Singh N, Master I, Lutckii A, Keshavjee S, Andersson J, Zumla A, Maeurer M (2015) Totally drug-resistant tuberculosis and adjunct therapies. J Intern Med 277(4):388–405 Paterson DL, Bonomo RA (2005) Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 18(4):657–686 Peacock SJ, Paterson GK (2015) Mechanisms of methicillin resistance in Staphylococcus aureus.

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