By Lester Packer, Enrique Cadenas
This new quantity of Methods in Enzymology keeps the legacy of this most advantageous serial with caliber chapters authored via leaders within the box. this can be the second one of 3 volumes on hydrogen peroxide and telephone signaling, and comprises chapters on such themes because the mobile steady-state of H2O2, evaluating peroxiredoxin sensitivity in the direction of inactivation through peroxide substrates, and peroxiredoxins as preferential goals in H2O2-induced signaling.
- Continues the legacy of this greatest serial with caliber chapters authored by means of leaders within the box
- Covers hydrogen peroxide and cellphone signaling
- Contains chapters on such issues as the mobile steady-state of H2O2, evaluating peroxiredoxin sensitivity in the direction of inactivation through peroxide substrates, and peroxiredoxins as preferential ambitions in H2O2-induced signaling
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Extra resources for Hydrogen Peroxide and cell signaling, Part B
Summary Acknowledgments References 4 6 9 10 11 12 12 13 14 16 16 16 17 18 18 Abstract Hydrogen peroxide (H2O2) is able to diffuse across biomembranes but, when cells are exposed to external H2O2, the fast consumption of H2O2 inside the cells due to H2O2removing enzymes provides the driving force for setting up a H2O2 gradient across the plasma membrane. Knowing this gradient is fundamental to standardize studies with H2O2 as for the same extracellular H2O2 concentration cells with different H2O2 gradients may be exposed to different intracellular H2O2 concentrations.
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In S. cerevisiae cells, the main H2O2-removing enzymes are cytosolic catalase (Ctt1p) and mitochondrial cytochrome c peroxidase (Ccp1p) (Minard & McAlister-Henn, 2001), although yeast cells also contain a peroxisomal catalase and several thiol-dependent peroxidases, including three non-selenium-dependent glutathione peroxidases (Avery & Avery, 2001; Wong, Siu, & Jin, 2004). A key issue to apply Eq. 4) is that H2O2removing enzymes operating in intact cells and in disrupted cells must be the same, otherwise the gradient obtained is not only due to cellular permeabilization.