Ion Channels by Bernardo Rudy (Eds.)

By Bernardo Rudy (Eds.)

This publication describes glossy electrophysiological innovations for recording and research of ion channels in quite a few structures together with cells in tradition, Xenopus oocytes, mind slices, mobile organelles, and microorganisms. Many chapters take care of the prevention and correction of electrophysiological artifacts. additionally incorporated are tools for the purification and expression of ion channel genes and proteins

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Ion Channels

This e-book describes sleek electrophysiological thoughts for recording and research of ion channels in quite a few platforms together with cells in tradition, Xenopus oocytes, mind slices, mobile organelles, and microorganisms. Many chapters take care of the prevention and correction of electrophysiological artifacts.

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Physiol. 6, 115 (1984). 2j. L. Rae, R. A. Levis,and R. S. Elsenberg,in "Ion Channels"(T. ), p. 283. Plenum, New York and London, 1988. METHODS IN ENZYMOLOGY, VOL. 207 Copyright © 1992 by Ac~lemic Press, Inc. All fights of repr~uction in any form reserved. PATCH CLAMP SETUP [2] I 15 Computer ] Filter t I PatchClamp ] Faraday Cage I Headstage Oscilloscope I -~'LTape Recorder~ I Micromanipulator ~-Micr°sc°pe I • 1 I Mounting Hardwarej [ ArTab e FIG. 1. Blockdiagramfor a patchclampsetup. ways in which investigators have implemented them, and suggest procedures that can result in very high quality patch clamp recordings.

Major 60-Hz (or 120-Hz) interference may come from fluorescent room lights and from the microscope light itself. Often, the microscope light is driven by alternating current derived from the line and stepped down by a transformer in the microscope. Whereas in some cases it is possible to ground the microscope and the power cord to the light to adequately shield against this problem, more often one must rewire the microscope so that the light can be driven from a low ripple direct current power supply.

207 Copyright © 1992 by Ac~lemic Press, Inc. All fights of repr~uction in any form reserved. PATCH CLAMP SETUP [2] I 15 Computer ] Filter t I PatchClamp ] Faraday Cage I Headstage Oscilloscope I -~'LTape Recorder~ I Micromanipulator ~-Micr°sc°pe I • 1 I Mounting Hardwarej [ ArTab e FIG. 1. Blockdiagramfor a patchclampsetup. ways in which investigators have implemented them, and suggest procedures that can result in very high quality patch clamp recordings. Figure 1 shows a block diagram of a patch clamp setup that includes the important elements that any set should have.

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