Journal of Orofacial & Health Sciences by Dr. Reena R. Kumar

By Dr. Reena R. Kumar

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BPTHERAPY 2 They have an inhibiting effect on metaloproteanases of metastatic cells and bring about apoptosis of neoplastic cells by disturbing Hence, it is important for the orthodontist to understand the limitations a patient on SP therapy presents when orthodontic treatment is needed. the mevalonate pathway. 2,9 Orthodontist should bear in mind that treatment of any severe medical condition or prevention of fractures has priority over orthodontic treatment, hence discontinuation of the drug by the orthodontist is not an available option.

REFERENCES 1. B. of osteoporosis 2007;131:311-320. with bisphosphonates Endocrinol. Metab. C1in. N. Am. 27: 1998, Ghoneima 7. AA, Allam ES, Zunt SL,Windsor treatment of patients using bisphosphonates: A report of 2 LJ: cases. AJO 2007; 131: 321-326. Bisphosphonate treatment and orthodontic considerations. 8. Graham John W. : Bisphosphonates and orthodontics: clinical implications. JeO 2006, Vol. XL no 7: 425 -428. Kim Tae-Weon, Yoshida Yoshie, Yokoya Koji and Sasaki Takahisa: An ultrastructural study of the effects of 4.

This would moderate to severe hypocalcaemia associated with additionally empower the orthodontist to decide the malignancy and also for the management of metastatic osteolytic lesions in association with breast cancer and multiple myeloma in conjunction with anti-neoplastic chemotherapeutic agents. 2 Children may also be administered bisphosphonate for bone conditions like osteogenesis imperfecta, fibrous dysplasia, juvenile or glucocorticoid osteoporosis and Gaucher's disease. 3 ,4 Hence, it has become essential in the present day for the orthodontist /trained junior dentist to partake in detailed medical/dental and drug history recording of adults and compromised children rather than leaving it to the front office who might miss valuable information due to lack of knowledge in this arena.

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