Lipobiology by van der Vusse (Eds.)

By van der Vusse (Eds.)

This quantity on lipobiology comprises 27 chapters facing a particular variety of matters of lipid homeostasis within the eukaryotic cells and mammalian physique. It makes a speciality of matters within the box of lipobiology characterized via new insights in underlying regulatory mechanisms. targeted awareness is paid to proteins keen on lipid move and enzymes in lipid metabolism and the rules of expression of genes encoding for lipid dealing with proteins.

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More recent work on the structure of the HSA –hemin –myristic acid complex, in which fatty acids were complexed with HSA at a 4:1 mole ratio, revealed a conformation that is intermediate between defatted HSA and the fully loaded HSA –fatty acid complex [73]. The structural basis for this intermediate state is being investigated but the observation nevertheless suggests that the conformational adaptability of HSA is perhaps even greater than was previously appreciated. Binding experiments that monitored the impact of fatty acids on the binding of other albumin ligands suggest that structural changes become evident at fatty acid to albumin mole ratios of less than 1 and are essentially complete when the ratio reaches a level of 3– 4 [2,74,75].

Faseb J. 14, 2040–2046. 28 I. Niot and P. , 2003. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid binding protein (L-FABP) gene. J. Biol. Chem. 1, 1. , 2000. Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling. J. Nutr. 130, 294S–298S. , 1993. The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI). Mol. Cell. Biochem. 123, 129–138. , 1993. Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A.

Thus, in sites 2, 4 and 5 which may be considered as linear tunnels, or in site 6 which is more of a surface groove, the different fatty acids bind in similar, extended configurations (Fig. 3). The presence of a single cis-double bond in oleic acid (C18:1) makes little detectable difference to the binding configuration; clearly, there is sufficient room in these channel-like sites to easily accommodate the kink introduced in the middle of the methylene tail [61]. Even arachidonic acid (C20:4) that has four cis-double bonds and is more restricted in its conformational freedom extends to a more-or-less linear configuration in these narrow sites.

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