By van der Vusse (Eds.)
This quantity on lipobiology comprises 27 chapters facing a particular variety of matters of lipid homeostasis within the eukaryotic cells and mammalian physique. It makes a speciality of matters within the box of lipobiology characterized via new insights in underlying regulatory mechanisms. targeted awareness is paid to proteins keen on lipid move and enzymes in lipid metabolism and the rules of expression of genes encoding for lipid dealing with proteins.
Read or Download Lipobiology PDF
Best molecular biology books
Fifty years in the past, James D. Watson, then simply twentyfour, helped release the best ongoing medical quest of our time. Now, with detailed authority and sweeping imaginative and prescient, he offers us the 1st complete account of the genetic revolution—from Mendel’s backyard to the double helix to the sequencing of the human genome and past.
A person drawn to comparative biology or the background of technological know-how will locate this myth-busting paintings really attention-grabbing. It attracts consciousness to the seminal experiences and critical advances that experience formed systematic and biogeographic pondering. It strains ideas in homology and class from the nineteenth century to the current throughout the provision of a different anthology of clinical writings from Goethe, Agassiz, Owen, Naef, Zangerl and Nelson, between others.
This e-book describes glossy electrophysiological options for recording and research of ion channels in quite a few platforms together with cells in tradition, Xenopus oocytes, mind slices, mobile organelles, and microorganisms. Many chapters care for the prevention and correction of electrophysiological artifacts.
This particular quantity covers molecular biology, mobile biology, biomarkers, imaging, and neuropathological equipment and strategies to discover a number of sclerosis (MS), with a different emphasis on illness types. With a lot attempt had to elucidate uncomplicated disorder mechanisms, to clone affliction appropriate genes, to outline novel biomarkers, and to find novel and stronger healing and healing remedies, this ebook serves to assist researchers in achieving those huge, immense objectives.
- BRS Biochemistry, Molecular Biology, & Genetics (Board Review Series) (6th Edition)
- Handbook of Cell Signaling
- Calculating the Secrets of Life: Applications of the Mathematical Sciences in Molecular Biology
- Transformations of Lamarckism: From Subtle Fluids to Molecular Biology (Vienna Series in Theoretical Biology)
Additional resources for Lipobiology
More recent work on the structure of the HSA –hemin –myristic acid complex, in which fatty acids were complexed with HSA at a 4:1 mole ratio, revealed a conformation that is intermediate between defatted HSA and the fully loaded HSA –fatty acid complex . The structural basis for this intermediate state is being investigated but the observation nevertheless suggests that the conformational adaptability of HSA is perhaps even greater than was previously appreciated. Binding experiments that monitored the impact of fatty acids on the binding of other albumin ligands suggest that structural changes become evident at fatty acid to albumin mole ratios of less than 1 and are essentially complete when the ratio reaches a level of 3– 4 [2,74,75].
Faseb J. 14, 2040–2046. 28 I. Niot and P. , 2003. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid binding protein (L-FABP) gene. J. Biol. Chem. 1, 1. , 2000. Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling. J. Nutr. 130, 294S–298S. , 1993. The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI). Mol. Cell. Biochem. 123, 129–138. , 1993. Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A.
Thus, in sites 2, 4 and 5 which may be considered as linear tunnels, or in site 6 which is more of a surface groove, the different fatty acids bind in similar, extended configurations (Fig. 3). The presence of a single cis-double bond in oleic acid (C18:1) makes little detectable difference to the binding configuration; clearly, there is sufficient room in these channel-like sites to easily accommodate the kink introduced in the middle of the methylene tail . Even arachidonic acid (C20:4) that has four cis-double bonds and is more restricted in its conformational freedom extends to a more-or-less linear configuration in these narrow sites.