Lung Biology in Health & Disease Volume 221 Inhalation by Anthony J. Hickey

By Anthony J. Hickey

Commonly up to date to mirror the outpouring of study within the box, this moment version records the speculation and useful usage of aerosols in inhalation remedy and tracks advances in aerosol formula, improvement, and alertness. providing readers with stories on body structure, metabolism, and pharmacokinetics for a transparent figuring out of the healing impression of lung aerosols, this consultant analyzes inhalation applied sciences for an enormous array of illnesses together with bronchial asthma, cystic fibrosis, COPD, pulmonary infectious illnesses, and diabetes.

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Additional resources for Lung Biology in Health & Disease Volume 221 Inhalation Aerosols: Physical and Biological Basis for Therapy, Second Edition

Sample text

Particle orientation is a critical factor in describing interception. Mathematical models of inhaled fibers have become ever more detailed, considering deposition within the whole lung (57), regional distributions (58,59), and localized deposition patterns (60–62). Empirical formulas for fiber deposition based on data from deposition experiments with simulated human airways and replica casts have been presented by Myojo (63) and Sussman et al. (64,65). Such theoretical and empirical findings, suitable for describing the airborne behavior of pharmacologic drugs as fibrous aerosols, should be integrated into improved aerosol therapy protocols (66–68).

Martonen TB, Katz I, Cress W. Aerosol deposition as a function of airway disease: cystic fibrosis. Pharin Res 1995; 12:96–102. Martonen TB, Zhang Z, Yang Y, Bottei G. Airway surface irregularities promote particle diffusion in the human lung. Rad Prot Dosim 1995; 59:5–14. Hickey AJ, Martonen TB, Yang, Y. Theoretical relationship of lung deposition to the fine article fraction of inhalation aerosols. Pharma Acta Helv 1996; 71:185–190. Zhang Z, Martonen TB. Comparison of theoretical and experimental particle diffusion data within human airway casts.

95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. Sbirlea-Apiou et al. Schroeter JD, Musante CJ, Hwang D, Burton R, Guilmette R, Martonen TB. Hygroscopic growth and deposition of inhaled secondary cigarette smoke in human nasal pathways. Aerosol Sci Technol 2001; 34:137–143. Martonen T, Fleming J, Schroeter J, Conway J, Hwang D. In silico modeling of asthma. Adv Drug Del Rev 2003; 55:829–849. Hofmann W. Modeling techniques for inhaled particle deposition: the state of the art.

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