By Wallace B. Morrison
This advisor for the prognosis and remedy of lymphomas in canines and cats is geared up into components: noncutaneous and cutaneous lymphomas. aiding the practitioner in picking lymphomas that may be handled and defining the end result that may be anticipated, the sensible advisor comprises exact dialogue concerning the review equipment used to aid prognosis lymphomas. those contain histological class, immunophenotyping, AgNOR overview, and medical laboratory findings, in addition to how those effects be sure the strategy of therapy. Lymphoma in canines and Cats includes designated guideline for using average chemotherapeutic protocols and radiation treatment besides diverse treatments corresponding to rescue and dietary treatment. Tables summarize instructed diagnostic work-ups, scientific staging and steered therapy protocols, while 25 colour photographs and 20 charts make it an excellent fast reference resource that each clinician must have on hand.
Published via Teton New Media within the united states and dispensed by CRC Press outside of North the US.
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Extra resources for Lymphoma in Dogs and Cats
74 MYELOFIBROSIS Myelofibrosis has been reported in both dogs and cats with lymphoma. Myelofibrosis can be associated with myeloproliferative disorders, secondary to bone marrow damage, distant cancer effects, or it may be of unknown cause. 71 EOSINOPHILIA The concentration of eosinophils is normally tightly regulated and accounts for a small segment of peripheral blood neutrophils. Eosinophilia can be harmful because of the proinflammatory effects of eosinophils, or it may be helpful because of their antiparasitic effects.
The higher the number of NORs observed, the greater the cell’s proliferative activity. Silver staining (agryrophilia) and light microscopic evaluation of lymphoma specimens will allow visualization of the NOR’s as nuclear dots called AGNORs. The prognostic value of AgNORs has been investigated in several feline and canine tumor types including lymphoma. The AgNOR frequency per tumor cell nucleus can be determined by averaging the AgNOR count in 100 cells from representative areas of a tumor when viewed by light microscopy under oil immersion (1000X).
3 mg/kg in saline intravenously over 2 hours was used effectively in one dog with hypercalcemia secondary to an apocrine gland adenocarcinoma. 70a Electrolyte abnormalities are recognized complications of bisphosphonate treatment in humans and have been observed in dogs (example; hypomagnesemia). Relief from hypercalcemia in dogs with lymphoma may last for weeks following treatment with bisphosphonates. 71 Some reports describe the incidence of hypercalcemia associated with lymphoma in dogs at up to 40%, and many hypercalcemic dogs with lymphoma have the mediastinal form.