Metallobiochemistry Part B Metallothionein and Related by John N. Abelson, Melvin I. Simon, James F. Riordan, Bert L.

By John N. Abelson, Melvin I. Simon, James F. Riordan, Bert L. Vallee

This ebook presents updated, cutting-edge equipment for the purification of metallothionein and similar proteins, for the examine of steel binding, for the quantitation of metallothionein, and for the research of the actual and organic houses of metallothionein. New perspectives of the constitution and serve as of metallothionein also are incorporated in a few chapters

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Garvey, and A. Armario, Am. J. Physiol. 254, E71 (1988). 36 F. O. Brady and B. S. Helvig, Am. J. Physiol. 247, E318 (1984). 37 F. O. Brady, LifeSci. 28, 1647 (1981). 38 F. O. Brady, B. S. Helvig, A. E. Funk, and S. H. Garrett, Experientia, Suppl. 52, 555 (1987). 39 j. Hidalgo, M. Giralt, J. S. Garvey, and A. Armario, Horm. Metab. Res. 20, 530 (1988). [4] SIGNIFICANCE OF METALLOTHIONEIN 33 AMP analogs on M T gene transcription are additive, suggesting that the two regulatory pathways are independent.

Huibregtse, D. R. Engelke, and D. J. Thiele, Proc. Natl. Acad. Sci. A. 86(1), 65 (1989). 25 D. J. Ecker, T. R. Butt, and S. T. Crooke, Met. Ions Biol. Syst. 25, 147 (1989). 26 p. C. Huang and L. Y. Lin, in "Biologically Active Proteins and Peptides" (S. H. Chiou, K. T. Wang, and S. H. ), p. 101. Academia Sinica Press, 1989. 27 D. J. Ecker, T. R. Butt, E. J. Sternberg, M. P. Neeper, C. Debouck, J. A. Gorman, and S. T. Crooke, J. Biol. Chem. 261, 16895 (1986). 28 D. J. Thiele, M. J. Walling, and D.

H. Garrett, Experientia, Suppl. 52, 555 (1987). 39 j. Hidalgo, M. Giralt, J. S. Garvey, and A. Armario, Horm. Metab. Res. 20, 530 (1988). [4] SIGNIFICANCE OF METALLOTHIONEIN 33 AMP analogs on M T gene transcription are additive, suggesting that the two regulatory pathways are independent. Bacterial infection also increases hepatic MT synthesis while decreasing serum zinc concentrations, which are characteristic of an acute phase response. 41 These effects can be mimicked by administration of endotoxin, although the lipopolysaccharide is not a primary inducer of MT synthesis.

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