Molecular Aspects of Anticancer Drug-DNA Interactions by Stephen Neidle, Michael J. Waring (eds.)

By Stephen Neidle, Michael J. Waring (eds.)

Show description

Read or Download Molecular Aspects of Anticancer Drug-DNA Interactions PDF

Similar molecular biology books

DNA: The Secret of Life

Fifty years in the past, James D. Watson, then simply twentyfour, helped release the best ongoing medical quest of our time. Now, with exact authority and sweeping imaginative and prescient, he provides us the 1st complete account of the genetic revolution—from Mendel’s backyard to the double helix to the sequencing of the human genome and past.

Foundations of Systematics and Biogeography

Somebody attracted to comparative biology or the heritage of technology will locate this myth-busting paintings certainly attention-grabbing. It attracts recognition to the seminal reviews and demanding advances that experience formed systematic and biogeographic considering. It strains techniques in homology and class from the nineteenth century to the current in the course of the provision of a distinct anthology of clinical writings from Goethe, Agassiz, Owen, Naef, Zangerl and Nelson, between others.

Ion Channels

This ebook describes sleek electrophysiological ideas for recording and research of ion channels in a variety of platforms together with cells in tradition, Xenopus oocytes, mind slices, mobile organelles, and microorganisms. Many chapters care for the prevention and correction of electrophysiological artifacts.

Multiple Sclerosis: Methods and Protocols

This special quantity covers molecular biology, mobile biology, biomarkers, imaging, and neuropathological tools and strategies to discover a number of sclerosis (MS), with a unique emphasis on illness versions. With lots attempt had to elucidate uncomplicated sickness mechanisms, to clone ailment appropriate genes, to outline novel biomarkers, and to find novel and more advantageous healing and healing remedies, this ebook serves to assist researchers in reaching those huge, immense targets.

Additional info for Molecular Aspects of Anticancer Drug-DNA Interactions

Sample text

As our knowledge of the precise mechanisms, and relative importance of, different alkylating agent-DNA interactions increases, coupled with an understanding of the relative importance and biological consequence of damage and repair at critical genomic sites, it may be possible to synthesize more efficient and selective agents. As a class the alkylating agents are likely to continue to play an important role in cancer chemotherapy in the future. References Arcamone, F. , Giuliani, F. , Penco, S.

2 A, thereby affording an unambiguous view of the structure of the complexes as well as their solvent environment. In addition, the isomorphism of those crystals facilitates structure determination using the molecular replacement method. One concern is related to the fact that those complexes, crystallized in the same P4 1212 lattice, may adopt a particular conformation favoured by the lattice packing. This has been shown not to be the case by at least two lines of strong evidence, discussed in detail later in this chapter.

Res. , 132, 178-185 Dolan, M. , Oplinger, M. and Pegg, A. E. (1988). Sequence specificity of guanine alkylation and repair. Carcinogenesis, 9, 2139-2143 Erickson, L. , Bradley, M. , Ducore, J. , Ewig, R. A. G. and Kohn, K. W. (1980a). DNA crosslinking and cytotoxicity in normal and SV40 transformed human cells treated with antitumor nitrosoureas. Proc. Natl Acad. Sci. USA, 77, 467-471 Erickson, L. , Sharkey, N. A. and Kohn K. W. (1980b). DNA crosslinking and mono adduct repair in nitrosourea-treated human tumour cells.

Download PDF sample

Rated 4.72 of 5 – based on 32 votes