Molecular Biology and Evolution of Blood Group and MHC by Colin P. Groves (auth.), Antoine Blancher MD, PhD, Jan Klein

By Colin P. Groves (auth.), Antoine Blancher MD, PhD, Jan Klein PhD, Wladyslaw Socha MD (eds.)

The booklet presents updated summaries at the major platforms of blood staff antigens and MHC molecules in nonhuman primates. for every method, the human antigens are defined and used as a reference for comparability with their opposite numbers in apes and monkeys. The emphasis is at the molecular constitution of the gene items, the evolutionary pathways and presumed mechanisms wherein the structures have developed. All articles are written in this type of manner that they could function an creation to the sphere for nonexperts and, whilst, as a guide for specialists. various tables, diagrams, and figures supply overviews of antigen constructions and their distribution in several species and evolutionary relationships. large reference lists consultant the reader throughout the literature on each one topic.

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1942). As proposed by Wiener and his coworkers (Wiener et al. 1942), saliva inhibition, together with the reverse testing of serum for anti-A and anti-B isoagglutination, became the standard procedure for ABO typing of primate species below the taxonomic level of anthropoid apes. Old World Monkeys Table 5 shows the updated information on the distribution of the ABO groups among Old World monkeys. The table gives pooled data for each species without, however, taking into account significant geographical and/or racial differences that were observed among various species of baboons (Brett et al.

The Lewis Blood Groups of Humans . . . . . . . . The Lewis Blood Groups of Nonhuman Primates . . . . . . Tests with Monoclonal Anti-Lea and Anti-Leb Antibodies . . . . . The Biosynthesis of the AB, H and Lewis Substances . . . . . . Tissue Distribution of the ABH Antigens in Humans and Nonhuman Primates . . . . . . . . . . . . . . . . . . . Practical Aspects of the Blood Group Serology of Apes and Monkeys . Blood Transfusion . .

The latter allele encodes for the fucosyltransferase responsible for the synthesis of the H substance, a precursor of the A or B determinants in erythroid cells (see below and Figs. 1, 2). Very rare individuals are known who do not express H or A and B on their red cells but show normal quantities of H (and, possibly, A and B substances) in their saliva (Solomon et al. 1965; Mollicone et al. 1988b; Le Pendu et al. 1983a, 1983b). Properties of this phenotype, called para-Bombay, suggest that expressions of H on the red cells and in saliva are, in fact, two independent traits, for which Oriol et al.

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